11–13 Among the different ligands pyrocatechol (PC, ortho-dihydroxybenzene) was found to be the simplest phenolic ligand that assembles with Fe III into a metal phenolic network (MPN).
9,10 We recently reported a coordination-driven approach to deposit thin amorphous films from a variety of phenolic ligands and metal ions. 7,8 One prominent example is polyphenolic films obtained via oxidative polymerization on templating surfaces. Considerable effort has been given to the fabrication of bioinspired functional coatings for application in medicine, optics and catalysis. Here, we report the one-step assembly of four different flavonoids upon coordination with Fe III ions into thin films on solid surfaces. 5,6 However, the preparation of thin surface-bound or free-standing films from dietary flavonoids has largely remained unexplored. Strategies to address this issue range from encapsulation of flavonoids into liposome or polymeric carriers 4 to synthetic modifications. 2,3 A drawback of most flavonoids is their poor water solubility. 1 Due to their human health benefits flavonoids have gained increasing attention for applications in anticancer treatment, protection against cardiovascular disease, and mitigation of inflammation.
Dietary flavonoids constitute an important class of plant polyphenols and are present in abundance in fruits, vegetables and leaves, where they fulfill diverse biological functions from pigmentation to defense against chemical and radiation damage. These films are expected to have potential applications in the pharmaceutical and food industries. Films formed from quercetin, myricetin, luteolin and fisetin show radical scavenging activity, a renowned feature of their parent flavonoids, and can be reused over multiple cycles.
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We assembled dietary, bioactive flavonoids into a metal coordinated network to form thin, surface-bound films and hollow capsules, overcoming the poor water solubility of free flavonoids.
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